Check Carefully (one)mitotane decreases levels of ergotamine by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Keep track of. Mitotane is a strong inducer of cytochrome P-4503A4; monitor when coadministered with CYP3A4 substrates for feasible dosage adjustments.omaveloxolone will reduce the extent or result of ergotamine by infl… Read More